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Diabetes mellitus is a term that covers several metabolic disorders characterized by an increase in the concentration of blood glucose (chronic hyperglycemia), which is related to deficiencies in the secretion and / or action of insulin.
The treatment of diabetes aims to normalize the patient's blood glucose, so that its continuous monitoring is necessary since the glucose concentrations in the body are highly variable.
Acute glycemic changes are determined by glucose measurement, either by a laboratory test or by a glucometer. This determination is highly affected by food intake throughout the day, so that the monitoring of glycemic changes in the long term is recommended the dosage of glycosylated proteins.
Protein glycosylation, exemplified in the figure above, is a natural process that is exacerbated in diabetes. Over time, sugar molecules bind to proteins in the blood, so the dosage of their glycosylation rate reflects the patient's glycemic average over the lifetime of that protein. Therefore, a higher concentration of glycosylated proteins indicates that blood glucose has remained above normal levels for an extended period.
Frutosamine is the popular term for non-enzymatic glycosylated proteins in the blood. Since the most abundant protein in the blood is albumin, the dosage of Frutosamine reflects the concentrations of glycosylated albumin. Therefore, this is a glycemic marker that reflects the glycemia observed in the 2 to 3 weeks prior to the exam.
In comparison with glycosylated hemoglobin (HbA1c), a widespread glycemic marker that reflects blood glucose from 6 to 8 weeks prior to the test, the measurement of fructosamine is clinically more interesting to monitor the treatment of diabetes. As albumin is a protein more sensitive to glycosylation, it has a faster response to glycemic changes than hemoglobin, which helps the physician to make faster decisions regarding the proposed treatment.
The joint use of the HbA1c and Frutosamine assays is even more valuable. As glycemic variations more quickly affect the dosage of fructosamine, the determination of high fructosamine levels associated with normoglycemic levels of HbA1c indicates that the patient is hyperglycemic for a short period. Therefore, the risk of complications linked to diabetes is low and can be reversed.
The opposite situation is also an excellent marker to indicate the efficiency of the treatment, since the glycemic drop will be reflected primarily by the reduction of the concentration of Frutosamine in the blood.
Biotécnica, always at the service of life, is launching a new Frutosamine determination kit composed of 2 reagents and with included calibrator. With the latest generation methodology and excellent performance against endogenous interferences, the kit still has linearity up to 800 µmol / L.
Count on Biotécnica for a correct and safe monitoring of glycemic profiles.
Fernanda Rebellato Giordano Martim
Biotécnica Ind. E Com. Ltda
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